The Expert Angle
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Medlior’s Expert Angle offers the inside track on new studies, industry hot topics, and what you need to know in the fast-paced world of clinical research, all from the point of view of the Medlior team of experts. From the latest topics and trends to the foundations of health and medical research, Medlior explores topics relevant to clients and the world.
MORSE and Medlior Join Forces
We are thrilled to announce a groundbreaking collaboration between Medlior Health Outcomes Research and MORSE Consulting, two leaders in the Canadian pharmaceutical market access landscape.
Pathways to early access in oncology
The pressure on payers to offer patients timely access to life-saving oncology medicines has increased with the rapid development of innovative treatments. Balancing the urgency to provide access with the need for evidence-based decision-making from phase III trials presents a significant challenge to publicly funded systems worldwide.
Cardiology trends during the COVID-19 pandemic
The COVID-19 pandemic had profound impacts on healthcare systems and patients around the world. Systems faced unprecedented challenges including resource reallocation, overwhelmed hospitals, and disruptions in routine care. Retrospective studies are now assessing the long-term cumulative effects of the pandemic and associated public health measures.
Methods Matter: Misinterpreting Covariate Coefficients from Multivariable Models
The Table 2 fallacy suggests that even after carefully identifying confounding variables (covariates) to adjust for, it is common for researchers to mistakenly interpret each coefficient from an adjusted regression model as the total effect of the covariate, which is not the case.
Methods Matter: Adjusting for the Wrong Covariates Can Introduce Bias Instead of Correcting it
Causal diagrams such as directed acyclic graphs (DAGs) can help in identifying a minimum set of confounding variables that need to be adjusted for. Arbitrarily dumping every available variable into a regression model can lead to biased estimates and incorrect conclusions about the effectiveness of a health intervention, its safety profile, and its downstream effects.
CADTH Symposium 2023: Is Canada Ready?
Medlior’s Founder and President Tara Cowling was delighted to attend the CADTH Symposium 2023 in Ottawa last week. On the heels of the ISPOR 2023 conference, CADTH also tackled some key issues surrounding the use of RWE to inform decision-making.
ISPOR 2023 in Boston
Hot-button items from the ISPOR 2023 conference included an emphasis on data quality, defining value, and caution with AI.
Treatment intensification and guideline LDL-C threshold achievement following acute myocardial infarction: Insights from a real-world evidence study
In a real-world Canadian population of high-risk patients with AMI, PCSK9i therapy in combination with other LLTs or alone was associated with better LDL-C reduction and higher proportions of patients meeting guideline thresholds; however, there was a longer time between the AMI event and PCSK9i treatments.
Accelerating access for rare diseases
For many rare diseases, the drug development process is particularly challenging. A multi-pronged approach to overcoming these challenges is underway.
2022: A Year in Review
As we slowly emerged from our COVID caves of 2020-2021, this year brought great excitement to Medlior. We helped industry bring life-changing innovations to market, and we increased our stakeholder collaboration.
Men’s Mental Health: A Silent Crisis
November is men’s health awareness month – and some of the less-often-talked about health issues affecting men are about their mental health. The Canadian Mental Health Association is calling this a “silent crisis, a sleeper issue”.
CADTH RWE Framework
I had the pleasure of attending the The Canadian Association for Population Therapeutics annual conference in Toronto, Canada. The program was titled “Embracing Change and Uncertainty to Improve the Health of Canadians” and it was kicked-off with a townhall session on Canadian RWE Initiatives...
